Journal article
Renal histopathology during experimental septic acute kidney injury and recovery
C Langenberg, G Gobe, S Hood, CN May, R Bellomo
Critical Care Medicine | Published : 2014
Abstract
OBJECTIVES:: Our understanding of septic acute kidney injury is limited. We therefore assessed renal histopathological changes induced by septic acute kidney injury and their evolution during recovery. DESIGN:: Prospective experimental study. SETTING:: Physiology Research Institute. SUBJECTS:: Twenty-two Merino sheep. INTERVENTION:: We induced septic acute kidney injury by continuous IV infusion of Escherichia coli. We studied histology, immunohistochemistry, markers of apoptosis, and expression of nitric oxide synthase isoforms and hypoxia-inducible factor-1α. Analysis was performed on kidneys from normal sheep, sheep with septic acute kidney injury, and sheep after recovery from septic acu..
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Grants
Awarded by National Health and Medical Research Council, Australia
Awarded by NHMRC
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
Supported, in part, by a grant 454615 from National Health and Medical Research Council, Australia, and the Victorian Government's Operational Infrastructure Support Program.Dr. Langenberg received grant support from Else-Kroener Fresenius Stiftung, Germany. Dr. Gobe received grant support from NHMRC and also for other project research from NHMRC. She is employed by the University of Queensland and lectures for Griffith University. Dr. May was supported by a NHMRC Research Fellowship (566819) and received support for international meeting expenses. His institution received grant support from NHMRC Australia. The remaining authors have disclosed that they do not have any potential conflicts of interest.